Estradiol
Abbreviation
E2
Preferred Specimen
Serum (fasting samples are recommended)
Minimum Volume
0.5mL
Alternative Specimens
None
Collection Instructions
Routine venipuncture
Transport Container
Draw tube or plastic transport tube
Transport Temp
2 – 8C
Stability
2-8 C up to 5 days
-20C up to 30 days
Methodology
CLIA (Chemiluminescent Immunoassay)
Reference Ranges
- Males: 16.2-44.5 pg/mL
- Menstruating females: Follicular: 16.2-122 Peri-ovulatory: 53.6-367 Luteal: 30.9-197
- Untreated Post-menopausal females: 16.2-65.7
Clinical Significance
Initial rise in Estradiol levels is useful for detecting pregnancy. Estradiol is also useful in evaluating a variety of other menstrual dysfunctions, feminization in children, and estrogen-producing tumors. May be elevated in gynecomastia and cirrhosis. Often measured in therapies aimed at overcoming infertility. Has been used in the differential diagnosis of amenorrhea and in the monitoring of ovulation induction.